AMID OF β-β-DIETHYLPROPIONIC ACID.



. To all whom it may concern:

UNITED STATES PATENT OFFICE.

LUnwIG' TAUB, or ELIBEBFELD, cnnmnnmnssrenon T0 FARBENFiiBRlKEN vQRM FRIEDR. BAYER & 00., on ELBERFELD, GERMANY, A CORPORATION or GERMANY.

AMID or p-p mETHYI PRoPIoNIo ACID.

Specification of Letters Patent. V Patented-NOV; 1910.

No Drawing. Original application filed October 21, 1909, Serial No. 523,805. Divided and this application filed February 15, 1910. Serial No. 543,978.

Be it known that I, LUDWIG propionic Acid, of which the tollowing is-a specification.

My invention relates to the manufacture and production of a new valuable pharmaceutical product which is chemically the amid of beta-beta-diethylpropionic. acid and which according, to my researches is a valuable'sedative.

The present app ication is a division of my application Seria No. 523,805, filed October 21,1909.

The new product is a crystalline compound soluble in hot alcohol-and'hot benzene. When reacted upon by hot alkalies it is split up into the beta-beta-diethylpropionic acid andammonia.

In carrying out my process practically I can proceed as'follows, the parts being by weight :390 parts of beta-beta-diethylpropicnic acid areheated to 100 C. with 140' parts of P01 the product of the'reaction is separated from the phosphoric acid by decantin of the formed acid chlorid and the chlori is distilled in vacuo. The chlorid of beta-beta-diethylpropionic acid is then treated with an excessof ammonia, the amid TA-UB, doctor of philosophy, chemist, citizen of the Geris filtered be and crystallized from benzene.

It is a' white crystallinepowder melting at 127.5 0., difii'cultly soluble in cold water,

more easily in hot water, soluble in hot alcohol and hot benzene; liberating the free acid when reacted upon by caustic alkaliand exhibiting valuable therapeutic especially sedative properties; an average dose being from 1} to 1 gram. The reaction proceeds in accordance with the following equations:

1. cn-cmcoon PC] 0,115 3 C2115 I QH cHcoo1+Nn ca on cons 1301 7 021154 2 m 3 Ca s a i I claim: s

The hereln-described new amid of betabeta-diethylpropionic acid being a white crystalline compound melting at 127.5 0.,

soluble in hot alcohol and hot benzene; liberating the free acid when reacted upon by. caustic alkali and. exhibiting valuable: therapeutic especially sedative properties, substantially as described.

In timony whereof'I-have hereuntoset my hand in the presence of two subscribing witnesses. v

.. LUDWIG TAUB. [L. s.]

Witnesses:

O'rro KoNIe, CHAS. J. WRIGHT. 

